Herpes simplex - Oddiy Gerpes
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Dudakdagi oddiy gerpes.
Oddiy Gerpes (Herpes simplex) ― Barmoqlardagi herpes simplex infektsiyasi kattalarga qaraganda yosh bolalarda ko'proq uchraydi.
References
HSV-1 infektsiyasi epiteliya hujayralarining birlamchi infektsiyasi, so'ngra kechikish, asosan neyronlarda va reaktivatsiya orqali o'tadi. HSV-1 odatda og'iz bo'shlig'i va jinsiy a'zolarning shilliq qavatida boshlang'ich va takrorlanuvchi vezikulyar portlashlarni keltirib chiqaradi. Uning namoyon bo'lishi orolabial herpesdan tortib, gerpetik follikulit, teri infektsiyalari, ko'zning shikastlanishi va gerpes ensefalit kabi og'ir holatlar kabi turli xil holatlarga qadar o'zgarib turadi. Antiviral terapiya HSV infektsiyasini boshqarishga yordam beradi.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) keng tarqalgan infektsiya bo'lib, Qo'shma Shtatlarda 12 va undan katta yoshdagi kattalarning taxminan 22 foizini ta'sir qiladi, jami 45 million kattalar. HSV-1 odatda og'iz bo'shlig'iga sabab bo'lsa-da, u genital lezyonlarga ham olib kelishi mumkin. Biroq, bemorlarda genital shikastlanishlar bo'lsa, HSV-2 odatda asosiy tashvish hisoblanadi. HSV-2 epidemiyasining alomatlari ko'pincha noaniq bo'lib, genital qichishish va tirnash xususiyati kabi, tashxis va davolanishni kechiktirishi mumkin. Ushbu kechikish infektsiyalanmagan shaxslarga keyingi yuqishiga olib kelishi mumkin.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) ko'pincha o'smirlar va kattalardagi genital gerpes va sovuq yaralar kabi infektsiyalarni keltirib chiqaradi. HSV chaqaloqni hayotning dastlabki 4-6 xaftasida yuqtirganda, bu jiddiy oqibatlarga olib keladigan og'ir kasallikka olib kelishi mumkin. Neonatal HSV infektsiyasini tezda tashxislash kasallikning kuchayishini to'xtatish, nevrologik muammolarni (hatto o'limni) oldini olish uchun juda muhimdir.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex INFEKTSION juda keng tarqalgan va homilador ayollardan ularning chaqaloqlariga o'tishi mumkin. Ushbu virus yangi tug'ilgan chaqaloqlarda jiddiy sog'liq muammolariga yoki hatto o'limga olib kelishi mumkin. Homiladorlikning o'zi kamdan-kam hollarda bo'lsa-da, ko'pincha tug'ruq paytida sodir bo'ladi. Agar ona homiladorlikning keyingi bosqichlarida yuqsa, xavf eng yuqori bo'ladi. Biroq, bu xavfni antiviral preparatlarni qo'llash yoki ma'lum holatlarda kesmani tanlash orqali kamaytirish mumkin.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) 1 va 2 turlari butun dunyo bo'ylab ko'p odamlarni yuqtiradi. Odatda, virus terini yuqtirganidan keyin asab hujayralarida jim bo'lib qoladi, ammo keyinroq qayta faollashishi mumkin, bu esa sovuq yaralarni keltirib chiqarishi mumkin. Ba'zida bu yangi tug'ilgan chaqaloqlarda va immuniteti zaif odamlarda ko'z infektsiyalari, miya yallig'lanishi yoki xavfli sharoitlar kabi jiddiy muammolarga olib keladi. Mavjud dori vositalari infektsiyalarni nazorat qilishda yordam bersa-da, dorilarga qarshilik va yon ta'sirlar xavfi tashvish bo'lib qolmoqda. Bizga virusni yaxshiroq yo'naltirish uchun yangi dorilar kerak.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
oddiy gerpes (herpes simplex) virusining ikki turi mavjud: 1-toifa (HSV-1) va 2-toifa (HSV-2). HSV-1 ko'pincha og'iz atrofidagi infektsiyalarni keltirib chiqaradi, HSV-2 esa genital infektsiyalarni keltirib chiqaradi. Ular infektsiyalangan odam bilan bevosita aloqa qilish orqali yuqadi. Genital herpes jinsiy yo'l bilan yuqadigan infektsiya sifatida tasniflanadi. Tug'ruq paytida chaqaloqqa yuqishi mumkin. INFEKTSION so'ng, viruslar hissiy nervlar bo'ylab nerv hujayralari tanasiga o'tkaziladi, ular umr bo'yi yashaydilar. Qayta paydo bo'lishining sabablari quyidagilardan iborat bo'lishi mumkin: immunitetning pasayishi, stress va quyosh nuriga ta'sir qilish.
Ko'pgina hollarda antiviral preparatlar faqat alomatlar og'ir bo'lganda olinadi. Har kuni virusga qarshi dori juda tez-tez infektsiyalangan odamga buyurilishi mumkin. Mavjud vaktsina yo'q va shingillaga qarshi emlash herpes simplexini oldini olmaydi. Asiklovir yoki valasiklovir kabi antiviral preparatlar bilan davolash simptomlarning og'irligini kamaytirishi mumkin.
Dunyo bo'ylab HSV-1 yoki HSV-2 darajasi kattalarda 60% dan 95% gacha. HSV-1 odatda bolalik davrida yuqadi. 2003 yil holatiga ko'ra, butun dunyo bo'ylab taxminan 536 million kishi (aholining 16%) HSV-2 bilan kasallangan, bu ayollar va rivojlanayotgan mamlakatlarda ko'proq. HSV-2 bilan kasallangan ko'pchilik odamlar infektsiyalanganligini bilishmaydi.
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Pufakchalar mavjud bo'lganda, bolani o'pish kabi har qanday jismoniy aloqadan saqlaning, chunki aloqa infektsiyani boshqa odamlarga yuqtirishi mumkin. Spirtli ichimliklarsiz dam olishingiz kerak.
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